解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:OBJECTIVE:To combine MRI-based cortical morphometry and diffusion white matter tractography to describe the anatomical correlates of repetition deficits in patients with primary progressive aphasia (PPA). METHODS:The traditional anatomical model of language identifies a network for word repetition that includes Wernic...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008746
更新日期:2020-02-11 00:00:00
abstract:OBJECTIVE:To compare the proportion of APOE ε4 genotype carriers in aphasic vs amnestic variants of Alzheimer disease (AD). METHOD:The proportion of APOE ε4 carriers was compared among the following 3 groups: (1) 42 patients with primary progressive aphasia (PPA) and AD pathology (PPA/AD) enrolled in the Northwestern ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008666
更新日期:2020-02-11 00:00:00
abstract:OBJECTIVE:We conducted a nationwide case-control study in Sweden to test the hypothesis that specific clinical characteristics are associated with increased risk of sudden unexpected death in epilepsy (SUDEP). METHODS:The study included 255 SUDEP cases (definite and probable) and 1,148 matched controls. Clinical infor...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008741
更新日期:2020-01-28 00:00:00
abstract:OBJECTIVE:To report the incidence of prion disease in the United States. METHODS:Prion disease decedents were retrospectively identified from the US national multiple cause-of-death data for 2003-2015 and matched with decedents in the National Prion Disease Pathology Surveillance Center (NPDPSC) database through compa...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008680
更新日期:2020-01-14 00:00:00
abstract:OBJECTIVE:To investigate whether baseline concentrations of plasma total tau (t-tau) and neurofilament light (NfL) chain proteins are associated with annual percent change (APC) of the basal forebrain cholinergic system (BFCS) in cognitively intact older adults at risk for Alzheimer disease (AD). METHODS:This was a la...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008696
更新日期:2020-01-07 00:00:00
abstract:OBJECTIVE:To determine whether cardiac magnetic resonance imaging (CMR) could be useful in identifying previously undiagnosed cardiomyopathies in a cohort of patients with ischemic stroke who underwent standard etiologic investigation and to describe the type and frequency of these cardiomyopathies. METHODS:We perform...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008698
更新日期:2020-01-07 00:00:00
abstract:OBJECTIVE:To test the hypothesis that transcranial magnetic resonance-guided focused ultrasound (tcMRgFUS) thalamotomy is effective, durable, and safe for patients with medication-refractory essential tremor (ET), we assessed clinical outcomes at 3-year follow-up of a controlled multicenter prospective trial. METHODS:...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0000000000008561
更新日期:2019-12-10 00:00:00
abstract:OBJECTIVE:To test the hypothesis that concussion-related brain alterations seen at symptomatic injury and medical clearance to return to play (RTP) will have dissipated by 1 year after RTP. METHODS:For this observational study, 24 athletes with concussion were scanned longitudinally within 1 week after injury, at RTP,...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008523
更新日期:2019-11-19 00:00:00
abstract:OBJECTIVE:There is a high risk of readmission within 30 days of index acute ischemic stroke (AIS), but effect of readmission to a different hospital is not known. We performed a retrospective cohort study to assess our hypothesis that 30-day readmission outcomes after AIS are worse for those readmitted to another hospi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008446
更新日期:2019-11-12 00:00:00
abstract::Recent positive trials have thrust acute cerebral perfusion imaging into the routine evaluation of acute ischemic stroke. Updated guidelines state that in patients with anterior circulation large vessel occlusions presenting beyond 6 hours from time last known well, advanced imaging selection including perfusion-based...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0000000000008481
更新日期:2019-11-12 00:00:00
abstract:OBJECTIVES:To quantify the quality of physicians' emergency first response to status epilepticus (SE) and to identify risk factors for nonadherence to treatment guidelines in a standardized simulated scenario. METHODS:In this prospective trial, 58 physicians (of different background) of the University Hospital Basel, ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008461
更新日期:2019-11-05 00:00:00
abstract:OBJECTIVE:To assess the onset of ocrelizumab efficacy on brain MRI measures of disease activity in the phase II study in relapsing-remitting multiple sclerosis (RRMS), and relapse rate in the pooled phase III studies in relapsing multiple sclerosis (RMS). METHODS:Brain MRI activity was determined in the phase II trial...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0000000000008189
更新日期:2019-11-05 00:00:00
abstract:OBJECTIVE:To prospectively investigate the relationships between serum tissue inhibitor metalloproteinase-1 (TIMP-1) and clinical outcomes in patients with acute ischemic stroke. METHODS:We derived data from the China Antihypertensive Trial in Acute Ischemic Stroke. Baseline serum TIMP-1 concentrations were measured i...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008389
更新日期:2019-10-29 00:00:00
abstract:OBJECTIVE:To report on the benefits of noninvasive vagus nerve stimulation (nVNS) on acute vestibular migraine (VM) treatment. METHODS:This was a retrospective chart review of patients with VM treated with nVNS in a single tertiary referral center between November 2017 and January 2019. Eighteen patients (16 women) we...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008388
更新日期:2019-10-29 00:00:00
abstract::Nodoparanodopathy is a recent concept in the field of peripheral neuropathy, corresponding to peripheral nerve disorders stemming from an autoimmune attack directed and limited to the nodal region. This concept was identified using modern techniques of electrophysiology, immunology, and pathology (including electron m...
journal_title:Neurology
pub_type: 历史文章,杂志文章
doi:10.1212/WNL.0000000000008399
更新日期:2019-10-29 00:00:00
abstract:OBJECTIVE:To define the natural history of the C9orf72 amyotrophic lateral sclerosis (C9ALS) patient population, develop disease biomarkers, and characterize patient pathologies. METHODS:We prospectively collected clinical and demographic data from 116 symptomatic C9ALS and 12 non-amyotrophic lateral sclerosis (ALS) f...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008359
更新日期:2019-10-22 00:00:00
abstract:OBJECTIVE:To investigate the prevalence of asymptomatic diffusion-weighted imaging-positive (DWI+) lesions in individuals with cerebral small vessel disease (SVD) and identify their role in the origin of SVD markers on MRI. METHODS:We included 503 individuals with SVD from the Radboud University Nijmegen Diffusion Ten...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008364
更新日期:2019-10-22 00:00:00
abstract:OBJECTIVE:To apply the ATN scheme to memory clinic patients, to assess whether it discriminates patient populations with specific features. METHODS:We included 305 memory clinic patients (33% subjective cognitive decline [SCD]: 60 ± 9 years, 61% M; 19% mild cognitive impairment [MCI]: 68 ± 9 years, 68% M; 48% dementia...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008361
更新日期:2019-10-22 00:00:00
abstract:OBJECTIVE:To use the large dataset from the Tysabri Outreach: Unified Commitment to Health (TOUCH) program to compare progressive multifocal leukoencephalopathy (PML) risk with natalizumab extended interval dosing (EID) vs standard interval dosing (SID) in patients with multiple sclerosis (MS). METHODS:This retrospect...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008243
更新日期:2019-10-08 00:00:00
abstract:OBJECTIVE:To develop a simple imaging rule to predict neurodevelopmental outcomes at 4.5 years in a cohort of preterm neonates with white matter injury (WMI) based on lesion location and examine whether clinical variables enhance prediction. METHODS:Sixty-eight preterm neonates born 24-32 weeks' gestation (median 27.7...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008172
更新日期:2019-09-24 00:00:00
abstract:OBJECTIVE:Activation of the type 1 interferon (IFN1) pathway is a prominent feature of dermatomyositis (DM) muscle and may play a role in the pathogenesis of this disease. However, the relevance of the IFN1 pathway in patients with other types of myositis such as the antisynthetase syndrome (AS), immune-mediated necrot...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008128
更新日期:2019-09-17 00:00:00
abstract:OBJECTIVE:To provide updated evidence-based recommendations for migraine prevention using pharmacologic treatment with or without cognitive behavioral therapy in the pediatric population. METHODS:The authors systematically reviewed literature from January 2003 to August 2017 and developed practice recommendations usin...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0000000000008105
更新日期:2019-09-10 00:00:00
abstract:OBJECTIVE:We hypothesized that cardiac electrical instability and abnormal autonomic tone result from cumulative cardiac injury sustained in recurrent seizures. We tested this hypothesis by comparing T-wave alternans (TWA) and heart rate variability (HRV), both established markers of sudden cardiac death (SCD) risk, in...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008077
更新日期:2019-09-03 00:00:00
abstract:OBJECTIVE:To evaluate the associations of mild behavioral impairment (MBI) with cognitive deficits and patterns of gray matter changes in Parkinson disease (PD). METHODS:Sixty patients with PD without dementia and 29 healthy controls underwent a cognitive neuropsychological evaluation and structural MRI scan. MBI was ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000007968
更新日期:2019-08-20 00:00:00
abstract:OBJECTIVE:To evaluate changes from baseline in patient-reported outcomes for measures of functioning and disability among patients with migraine treated with galcanezumab or placebo. METHODS:Patients with episodic migraine (4-14 monthly migraine headache days) were treated with either galcanezumab (Evaluation of LY295...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0000000000007856
更新日期:2019-07-30 00:00:00
abstract:OBJECTIVE:To identify independent predictors of clinical or cerebral lesion progression in a large sample of adult patients with moyamoya angiopathy (MMA) prior to decisions regarding revascularization surgery. METHODS:Ninety participants (median age, 37.5 years) were assessed at baseline and followed for a median tim...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000007819
更新日期:2019-07-23 00:00:00
abstract:OBJECTIVE:Diagnostic criteria from 2002 classify transverse myelitis (TM) as idiopathic or disease associated but predate the discovery of aquaporin-4 (AQP4)-immunoglobulin G (IgG) and myelin oligodendrocyte glycoprotein (MOG)-IgG, which associate with TM. Prior incidence estimates of idiopathic TM (ITM) range from 1 t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000007828
更新日期:2019-07-23 00:00:00
abstract:OBJECTIVE:To verify the previously reported association between long-term use of β2-adrenoreceptor (β2AR) agonist and antagonist with reduced and increased risk of Parkinson disease (PD), respectively. METHODS:We obtained odds ratios (ORs) associating time of β2AR agonist and antagonist use with PD risk in nationwide ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000007694
更新日期:2019-07-09 00:00:00
abstract::In the current medical climate, medical education is at risk of being de-emphasized, leading to less financial support and compensation for faculty. A rise in compensation plans that reward clinical or research productivity fails to incentivize and threatens to erode the educational missions of our academic institutio...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000007664
更新日期:2019-07-02 00:00:00
abstract:OBJECTIVE:Compare the cost and effectiveness of nonbenzodiazepine antiepileptic drugs (non-BZD AEDs) for treatment of BZD-resistant convulsive status epilepticus (SE). METHODS:Decision analysis model populated with effectiveness data from a systematic review and meta-analysis of the literature, and cost data from publ...
journal_title:Neurology
pub_type: 杂志文章,meta分析
doi:10.1212/WNL.0000000000007503
更新日期:2019-05-14 00:00:00
abstract:OBJECTIVE:Given the limited information on cognitive function before Parkinson disease (PD) clinical onset in the general population, we sought to assess prodromal PD (pPD) probability and relate it to detailed cognitive performance in a community cohort. METHODS:In a population-based cohort of 1,629 dementia-free and...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000007453
更新日期:2019-05-07 00:00:00
abstract:OBJECTIVE:To compare the clinical features of patients showing a classical phenotype of facioscapulohumeral muscular dystrophy (FSHD) with genetic and epigenetic characteristics of the FSHD1 and FSHD2 loci D4Z4 and SMCHD1. METHODS:This is a national multicenter cohort study. We measured motor strength, motor function,...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0000000000007456
更新日期:2019-05-07 00:00:00
abstract:OBJECTIVE:To assess whether hippocampal sclerosis (HS) severity is mirrored at the level of large-scale networks. METHODS:We studied preoperative high-resolution anatomical and diffusion-weighted MRI of 44 temporal lobe epilepsy (TLE) patients with histopathologic diagnosis of HS (n = 25; TLE-HS) and isolated gliosis ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000007447
更新日期:2019-05-07 00:00:00
abstract:OBJECTIVE:To determine the effect of erenumab, a human monoclonal antibody targeting the calcitonin gene-related peptide receptor, on health-related quality of life (HRQoL), headache impact, and disability in patients with chronic migraine (CM). METHODS:In this double-blind, placebo-controlled study, 667 adults with C...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0000000000007452
更新日期:2019-05-07 00:00:00
abstract:OBJECTIVE:To investigate the efficacy and safety of aceneuramic acid extended-release (Ace-ER), a treatment intended to replace deficient sialic acid, in patients with GNE myopathy. METHODS:UX001-CL301 was a phase 3, double-blind, placebo-controlled, randomized, international study evaluating the efficacy and safety o...
journal_title:Neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1212/WNL.0000000000006932
更新日期:2019-04-30 00:00:00
abstract:OBJECTIVE:To determine if migraine with aura is associated with neuroinflammation, which has been suggested by preclinical models of cortical spreading depression (CSD) as well as imaging of human pain conditions. METHODS:Thirteen migraineurs with aura and 16 healthy controls received integrated PET/MRI brain scans wi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000007371
更新日期:2019-04-23 00:00:00
abstract:OBJECTIVE:To investigate whether arginine methylation is altered in patients with amyotrophic lateral sclerosis (ALS) and how it affects disease severity, progression, and prognosis. METHODS:We compared the immunoreactivity of protein arginine methyltransferase 1 (PRMT1) and its products, asymmetric dimethylated prote...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000007311
更新日期:2019-04-16 00:00:00
abstract:OBJECTIVE:Hospital readmission is an important quality improvement measure that has not been well-studied in pediatric neurology. We examined predictors of 7-day and 30-day readmissions for pediatric patients hospitalized with a neurologic diagnosis. METHODS:This was a retrospective study of hospital readmission rates...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000007280
更新日期:2019-04-16 00:00:00
abstract:OBJECTIVE:To assess functional changes in lymphocyte repertoire and subsequent clinical implications during delayed-release dimethyl fumarate (DMF) treatment in patients with multiple sclerosis. METHODS:Using peripheral blood from several clinical trials of DMF, immune cell subsets were quantified using flow cytometry...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000007262
更新日期:2019-04-09 00:00:00
abstract:OBJECTIVE:To revise the 1999 Airlie House consensus guidelines for the design and implementation of preclinical therapeutic studies and clinical trials in amyotrophic lateral sclerosis (ALS). METHODS:A consensus committee comprising 140 key members of the international ALS community (ALS researchers, clinicians, patie...
journal_title:Neurology
pub_type: 共识发展会议,杂志文章
doi:10.1212/WNL.0000000000007242
更新日期:2019-04-02 00:00:00